MBT STAR-BL software for patented functional beta-lactamase
testing is first high-value module in new MBT STAR (Selective Testing of
Antibiotic Resistance) family.
BARCELONA, Spain--(BUSINESS WIRE)--
At the 24th European Congress of Clinical Microbiology and Infectious
Diseases (ECCMID), Bruker introduces new and expanded research-use only
(RUO) capabilities for the MALDI Biotyper™ platform.
MBT Galaxy (Photo: Business Wire)
The MALDI Biotyper (MBT) is the market-leading system for
microbial identification based on MALDI-TOF mass spectrometry. It is
widely used in industrial microbiology, animal health, food safety and
its IVD and FDA-cleared versions are changing the paradigm in clinical
microbiology. With nearly 1,200 customer systems, the MBT platform has
become an accepted laboratory-standard for next-generation microbial
identification and emerging further high-value functional assays. The MALDI
Biotyper RUO and IVD-CE versions cover a broad range of about 2,300
species with more than 5,600 well-characterized microbial isolates from
gram-negative bacteria, gram-positive bacteria, yeasts, multicellular
fungi and mycobacteria. Microbial identification with the MALDI
Biotyper is done using proteomic fingerprinting, where unique
species-specific patterns are automatically compared with reference
spectra in the MALDI Biotyper library.
Due to the modular design of the MALDI Biotyper software, the
system can be configured according to the specific needs of each
laboratory: the basic microbial identification functionality is now
available in versions for clinical routine laboratories (IVD), for
industrial applications and for research-use-only (RUO) purposes.
Industrial and research customers can configure their MALDI Biotyper
systems with further functionality by adding various new or expanded RUO
software modules or hardware accessories:
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The MBT Explorer module provides multiple sophisticated
bioinformatics approaches for spectra comparison, statistical data
interpretation and for the generation of customer-specific reference
library entries (main spectra) of strains of special interest. Such
sub-libraries can be exported and re-imported in networks of
collaborating laboratories.
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The MBT Satellite module allows for an efficient
paperless setup. Multiple MBT Satellite modules can be used for
laboratories with multiple microbiology work-benches.
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The MBT Sepsityper module supports the analyses of data
generated from positive blood culture samples. This software
complements the MALDI Sepsityper kit with streamlined data
interpretation for this workflow.
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The MBT STAR-BL (Beta Lactamase) module is part
of the new MBT STAR assay family for Selective Testing
of Antibiotic Resistance, and enables patented
functional beta-lactamase testing for selected antibiotics. The MBT
STAR-BL software monitors the mass shifts introduced by enzymatic
degradation of betalactam antibiotics, like some penicillins, 3rd
generation cephalosporins and carbapenems. These changes are monitored
by direct measurements of molecular weights without the need of any
labelling by probes or antibodies. Bruker is currently gathering
feedback from infectious disease researchers on its performance. Due
to strong demand for this type of resistance information, future IVD
versions are planned.
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As use of the MALDI Biotyper continues to increase for
industrial microbiology in pharma, food or consumer goods industries,
data integrity topics like user management, audit trail and data
archiving are of special importance. For these customers, Bruker now
offers the new MBT Compliance Assistance Module to
support 21 CFR Part 11 requirements.
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MBT Translator and MBT Integrator modules
provide functionality to connect data generated with the MALDI
Biotyper to laboratory information systems (LIS). MALDI Biotyper
results are translated into the language of the LIS and are integrated
with information available in the LIS.
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The MBT Pilot™ is a hardware accessory to
support the light-guided preparation of target plates. In combination
with the MBT Satellite software it allows for a paperless and
barcode-tracked workflow with full traceability. The
ergonomically-shaped MBT Pilot guides users during the
preparation of plates, reducing the possibility of specimen transfer
errors.
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The MBT Galaxy™ reduces the manual workload
during preparation of sample target plates and also introduces
significant quality control steps, like controlled reagent droplet
size, controlled drying atmosphere and control of quality of the
matrix preparation. This bench-top automation device standardizes the
preparation of samples with quality controls for reagent additions.
The MBT Galaxy eliminates the need for manual reagent
pipetting, reducing repetitive motions and labor costs required for
target preparation. The MBT Galaxy is equipped with on-board
barcode reading to connect directly to the MALDI Biotyper
server.
Dr. Ulrich Eigner, Head of Study Department at Limbach Laboratory in
Heidelberg, Germany, commented: “We have been working with Bruker´s MALDI
Biotyper system in our network of microbiology laboratories for
several years and we are very pleased with the analytical performance.
With the MBT Pilot and MBT Galaxy Bruker now introduces
further smart and convincing workflow improvement tools.”
Dr. Wolfgang Pusch, Executive Vice President - Microbiology Business at
Bruker Daltonics, explained: “We believe that our MALDI Biotyper
can now provide even more than best-in-class identification to
microbiology laboratories. That’s why we are continuously working on
adding additional high-value functional assays, new software tools,
library extensions and productivity tools to the MALDI Biotyper platform.”
About the Bruker MALDI Biotyper
The MALDI Biotyper family of systems enables molecular identification,
and taxonomical classification or dereplication of microorganisms like
bacteria, yeasts and fungi. Classification and identification of
microorganisms is achieved reliably and quickly using proteomic
fingerprinting by high-throughput MALDI-TOF mass spectrometry. The MALDI
Biotyper uses a molecular approach based on specific proteomic
fingerprints from bacterial strains and published studies have
highlighted the greater accuracy and lower cost offered, as well as the
typically much faster time-to-result (TTR).
Applications of the various MALDI Biotyper solutions include clinical
routine microbial identification, environmental and pharmaceutical
analysis, taxonomical research, food and consumer product safety and
quality control, as well as marine microbiology. In many European and
international laboratories the MALDI Biotyper has replaced classical
biochemical testing for bacterial identification in the past five years
due to the accuracy, speed, extensive species coverage, ease of use and
cost effectiveness of the system. Classical biochemical techniques
detect different metabolic properties of microorganisms, can take many
hours or even days for completion, and they often lack specificity.
The robust MALDI Biotyper method requires minimal sample preparation and
offers low consumables cost. The products of the MALDI Biotyper family
are available in a research-use-only (RUO) version, as the U.S.
FDA-cleared MALDI Biotyper CA System, or in an IVD-CE version according
to EU directive EC/98/79. The MALDI Biotyper also has medical device
registrations in numerous other countries. RUO versions of the MALDI
Biotyper even allow selected high-value antimicrobial resistance tests
in translational research.
ABOUT BRUKER CORPORATION (NASDAQ: BRKR)
Bruker is a leading
provider of high-performance scientific instruments and solutions for
molecular and materials research, as well as for industrial, diagnostics
and applied analysis. For more information: www.bruker.com.
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Source: Bruker Corporation