Bruker's Novel ultrafleXtreme(TM) with 1 kHz smartbeam-II(TM) Laser Technology Redefines MALDI-TOF/TOF Performance for Proteomics, Biomarker Discovery and Quantitation, Biopharma QC, Tissue Molecular Imaging and Top-Down Sequencing
BILLERICA, Mass.--(BUSINESS WIRE)--Apr. 27, 2009--
Bruker Daltonics today launches its next-generation ultrafleXtreme™
MALDI-TOF/TOF mass spectrometer, the only instrument combining
true 1 kHz speed in both TOF and TOF/TOF modes with ultra-high
performance and extreme flexibility for a broad variety of complementary
research, clinical and applied proteomics applications. In proteomics,
MALDI-TOF/TOF is highly complementary to ESI-MS/MS with Bruker’s latest
high-capacity ion traps with ETD, and to ultra-high resolution (UHR)
ESI-Q-q-TOF maXis™ systems, as both MALDI and ESI are
required for highest coverage and flexibility in modern protein analysis.
The new ultrafleXtreme incorporates key inventions,
Bruker’s proprietary smartbeam-II™ laser technology at 1
kHz, and the latest ion optics innovations. It is the only MALDI-TOF/TOF
instrument that truly enables high-throughput 1 kHz biomarker discovery
and quantitation, as well as fast, high-performance tissue molecular
imaging with a laser spot size close to single cell spatial resolution.
LC-MALDI can be performed with unmatched mass resolution, mass accuracy
and data acquisition speed. Bruker’s unique Edmass™
protein sequencing capabilities allow very rapid and sensitive intact
protein characterization and sequencing with read lengths up to and
beyond 80 residues, and with direct analysis of N- and C- terminal
modifications.
Industry-leading TOF/TOF technology is incorporated into the ultrafleXtreme
for unprecedented capabilities:
-
The novel full 1 kHz smartbeam-II laser enables ultra-high
data acquisition speed in both MS and MS/MS at full systems
performance. The well-established proprietary smartbeam
laser provides unprecedented analytical and matrix flexibility in
workflows from protein tissue imaging, intact proteins analysis,
biologics or oligo QC, to LC-MALDI proteomics - all fully enabled at
1-1000 Hz repetition rates.
-
Broadband mass resolving power up to 40,000 enables precision
proteomics via Bruker’s unique PAN™ technology for highest mass
resolution across a very broad mass range, not just at a selected
optimum.
-
The novel FlashDetectorTM combined with a new
4 GHz digitizer and latest advances in electronics
provide unmatched mass resolving power up to 40,000
and 1 ppm mass accuracy for highest confidence.
-
Bruker’s patented smartbeam technology is already widely
accepted as the most viable MALDI imaging laser technology. The ultrafleXtreme
now enables laser focus diameters down to 10 µm
for high spatial resolution imaging without pixel overlap.
Importantly, outstanding spectral quality and signal intensity are
maintained at even the smallest laser beam diameters.
-
The novel and unique laser-irradiation self-cleaning MALDI
Perpetual™ Ion Source ensures robust, long-term
highest-performance operation. Very long MALDI laser lifetime in
combination with automated source cleaning in just minutes leads to
high uptime and low maintenance costs.
Efficient data retrieval and interpretation is provided by fully integrated
software platforms designed, progressed and supported by Bruker with
leading proteomics experts, for:
-
ProteinScape™ 2.0
ensures confident information from quantitative studies using either
label-free or ICPL™-4plex, SILAC, iTRAQ™-8plex or
user-defined label technologies, integrates multiple datasets across
large proteomic studies and generates reports in accordance to
standard publication guidelines.
-
BioTools™ 3.2
is the market-leading bioinformatics platform, now extended to
top-down protein sequencing for recombinant protein work, e.g. in
biotherapeutics and biosimilars characterization and QC.
-
flexImaging™
2.1 is the true gold standard in biomarker discovery based on
MALDI tissue molecular imaging and is fully compatible with clinical
histology.
Bruker Daltonics Executive Vice President Dr.
Ian Sanders
commented:
“Its incredible flexibility and unparalleled performance make the truly
innovative ultrafleXtreme the definitive MALDI-TOF/TOF
today. Researchers are enabled for new achievements in proteomics and
MALDI imaging, while achieving result quality across the board that
would have been undreamed of even a short time ago.”
The capabilities of the new ultrafleXtreme™ will be
highlighted at Bruker's Annual Users Meeting on Sunday, May 31st,
2009 before the 57th ASMS Conference on Mass Spectrometry in
Philadelphia, PA. For more information on this event, please visit www.bdal.com/asms2009.
For further product information please visit www.bdal.com/ultrafleXtreme.
ultrafleXtreme, ProteinScape, PAN, smartbeam, FlashDetector,
MALDI Perpetual, BioTools, ProteinScape, FlexImaging are trademarks of
Bruker Daltonik GmbH. ICPL is a trademark of TopLab GmbH, and iTRAQ is a
trademark of Applied Biosystems.
About Bruker Daltonics: For more information about Bruker
Daltonics and Bruker Corporation (NASDAQ: BRKR), please visit www.bdal.com
and www.bruker.com.
Photos/Multimedia Gallery Available: http://www.businesswire.com/cgi-bin/mmg.cgi?eid=5949225&lang=en
Source: Bruker Daltonics
Bruker Daltonics
Darwin Asa, Ph.D., +1 978-663-3660, ext. 1149
Life-Science
Marketing Manager
dja@bdal.com